5-MAPB Fumerate

5-MAPB Fumarate is a research chemical belonging to the benzofuran-class of compounds, widely studied for its structural similarities to entactogenic amphetamines. Chemically known as 1-(benzofuran-5-yl)-N-methylpropan-2-amine fumarate, it is primarily utilized in analytical and scientific investigations. 5-MAPB is notable for its benzofuran core—an aromatic ring fused with a furan ring—which is linked to a methylated amine group via a propyl side chain. This contributes to its unique configuration and allows for comparative studies with related substances, such as MDMA and 6-APB.

Chemical Properties and Structure

5-MAPB Fumarate has a molecular formula of C12H15NO·C4H4O4, reflecting its composition as the fumarate salt. The fumarate preparation enhances stability and facilitates precise measurements in laboratory settings due to its crystalline nature. This form allows researchers to work with consistent, defined samples. Its molar mass, approximately 295.3 g/mol, ensures compatibility with mass-based analytical techniques like gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). Solubility in organic solvents such as methanol or ethanol further enhances its utility in solution-based research methodologies.

Analytical Applications

Researchers investigate 5-MAPB Fumarate for its ability to bind with known receptor sites in neurological and biochemical studies, particularly focusing on its affinity for serotonin, dopamine, and norepinephrine transporters. Due to its structural similarity to MDMA, it is of interest in studies about neurotransmitter activity, receptor-ligand interactions, and potential entactogenic responses. 5-MAPB’s conformational profile enables researchers to explore how subtle changes in molecular structure impact transporter binding and serotonin release, advancing understanding of phenethylamine-class compounds.

Analytical studies also include quantifying 5-MAPB Fumarate’s purity through standard procedures, such as nuclear magnetic resonance (NMR) spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. These tests confirm the integrity of the compound, enabling reliable experimental outcomes. A combination of thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) ensures precise compound identification and component isolation.

Safety and Handling

As with all research chemicals, proper handling and storage of 5-MAPB Fumarate are paramount. It should be stored in a cool, dry environment away from direct sunlight and moisture to preserve its stability. Researchers must adhere to appropriate safety protocols, including the use of personal protective equipment (PPE) such as gloves, goggles, and lab coats. Working in a well-ventilated laboratory or under a fume hood minimizes the risks of accidental exposure.

Regulations and Research Limitations

The use of 5-MAPB Fumarate is restricted to certified research facilities and licensed professionals, adhering to applicable federal, state, and local regulations. It is not approved for human or veterinary use, and no clinical data supports its safety outside controlled environments. Researchers studying this compound are required to comply with ethical research practices and document their findings transparently to contribute to the scientific community responsibly.

Summary

5-MAPB Fumarate provides researchers with an opportunity to investigate the intersection of chemistry and neurobiology by examining its distinct molecular structure and its interactions with biological systems. While its potential insights are significant, studies must be conducted with meticulous attention to safety, legality, and ethical considerations. Through careful research and responsible methodologies, the study of 5-MAPB Fumarate continues to enhance knowledge within the fields of pharmacology and biochemistry.