What is Pagoclone and how does it work?

Pagoclone is a non-benzodiazepine of the cyclopyrrolone class. It acts as a partial agonist at GABA-A receptors, specifically targeting the alpha-2 and alpha-3 subunits, which are traditionally associated with anxiolytic properties in research models.

How does Pagoclone differ from Zopiclone?

While both are cyclopyrrolones, Pagoclone is a partial agonist, whereas Zopiclone is a full agonist. This difference in intrinsic activity makes Pagoclone a unique subject for studying the separation of sedative and anxiolytic receptor responses.

What is the purity of Eurochems Pagoclone?

Our Pagoclone is batch-tested via HPLC to guarantee a minimum purity of 98%, ensuring consistent and reproducible results for professional scientific research and forensic analysis.

What are the storage requirements for Pagoclone?

To ensure maximum shelf-life, Pagoclone should be stored in a cool, dry place away from direct sunlight. Using an airtight container is recommended to protect the crystalline structure from environmental degradation.

Pagoclone

Price range: € 40,00 through € 1.125,00

High-purity Pagoclone crystalline powder for professional research.

Purity: >98% HPLC Certified.
Class: Cyclopyrrolone / Non-benzodiazepine $GABA_{A}$ ligand.
Mechanism: Selective partial agonist ( $\alpha 2$ / $\alpha 3$ subunits).
Application: Forensic profiling and neuroscience research.
Shipping: Secure, discreet, and tracked worldwide delivery from Eurochems.

SKU: N/A Categories: Benzodiazepines, New Products, Research Chemicals

Description
Additional information

High-Purity Pagoclone – Premium Cyclopyrrolone Reagent for $GABA_{A}$ Research

Advance your laboratory’s understanding of non-benzodiazepine ligands with our high-purity Pagoclone. Pagoclone is a potent member of the cyclopyrrolone family, structurally related to Z-drugs like zopiclone. As a partial agonist at the $GABA_{A}$ receptor, Pagoclone is of significant interest to the scientific community due to its high affinity for $\alpha 2$ and $\alpha 3$ subunit-containing receptors, while exhibiting relatively low intrinsic activity at the $\alpha 1$ subunit.

The Pagoclone Research Advantage

Subunit Selectivity: Unlike traditional full agonists, Pagoclone’s partial agonist profile allows researchers to study the isolation of anxiolytic effects from sedative-hypnotic properties in various in-vitro and in-vivo models.
Structural Integrity: Supplied as a stable crystalline solid, our Pagoclone maintains high molecular integrity under standard laboratory conditions, ensuring a reliable analytical footprint for longitudinal studies.
HPLC-Verified 98%+ Purity: At Eurochems, we eliminate the variables. Every batch is subjected to High-Performance Liquid Chromatography (HPLC) testing to ensure it is free from synthesis precursors and unreacted intermediates.

Analytical Utility

Pagoclone serves as a vital reference standard for forensic toxicology and medicinal chemistry. Its distinct mass spectrometry fragmentation pattern allows for clear identification in complex chemical matrices. Researchers utilize this compound to map the pharmacophore of the cyclopyrrolone class and explore the metabolic pathways of $GABA_{A}$ modulators.

Safety & Storage Information

Pagoclone is intended strictly for forensic, laboratory, and analytical research