1V-LSD

1V-LSD is a lysergamide prodrug that converts to LSD in the body. It was popular in Germany before recent scheduling.

The history of 1V-LSD traces back to the research into lysergic acid derivatives that began in the mid-20th century. Following Albert Hofmann's groundbreaking discovery of LSD in 1943, researchers have continuously explored structural modifications to understand structure-activity relationships in ergoline compounds. 1V-LSD emerged as part of this ongoing research into prodrugs and analogs of classical psychedelics. Research into 1V-LSD gained momentum in the early 21st century as part of broader investigations into legal alternatives to controlled substances. Scientists studying serotonin 5-HT2A receptor pharmacology recognized the compound's value as a research tool for understanding how subtle structural modifications affect receptor binding affinity and functional activity. The compound has since become an important reference standard in analytical chemistry laboratories worldwide. Academic institutions and pharmaceutical research facilities have utilized 1V-LSD to advance our understanding of psychedelic pharmacology, particularly regarding receptor selectivity, metabolic pathways, and structure-function relationships. This research has contributed valuable data to the fields of neuropharmacology and medicinal chemistry, helping researchers develop more selective therapeutic compounds.

As a lysergamide derivative, 1V-LSD acts primarily on serotonin 5-HT2A receptors in the brain, producing characteristic psychedelic effects. Research suggests this compound binds to these receptors with high affinity, triggering downstream signaling cascades that modulate perception, cognition, and mood.

1V-LSD holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.

High-purity 1V-LSD (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.