4-AcO-MET
Metacetin
Overview
4-AcO-MET is a synthetic tryptamine prodrug used in research on psilocin-related compounds and serotonin pharmacology.
The history of 4-AcO-MET is rooted in the extensive research into tryptamine compounds that began with the isolation and characterization of naturally occurring indole alkaloids. Scientists have long been fascinated by tryptamines due to their structural similarity to serotonin (5-HT) and their profound effects on consciousness and perception. Research into 4-AcO-MET represents a continuation of this scientific tradition. Following Alexander Shulgin's pioneering work documenting substituted tryptamines in his research notebooks and publications, modern chemists have synthesized and characterized numerous analogs to understand structure-activity relationships. 4-AcO-MET emerged as a compound of interest for its unique pharmacological profile and potential applications in neuroscience research. The compound has been studied for its interactions with various serotonin receptor subtypes. Today, 4-AcO-MET serves as an important research tool in laboratories studying serotonin pharmacology, receptor binding mechanisms, and the neural correlates of altered states of consciousness. Its use in analytical chemistry as a reference standard has contributed to advances in detection methods and quality control protocols for novel psychoactive substances.
As a tryptamine compound, 4-AcO-MET structurally resembles serotonin (5-HT) and interacts with various serotonin receptor subtypes. This interaction modulates neurotransmission pathways, making it valuable for pharmacological research into indolealkylamine function.
4-AcO-MET holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.
High-purity 4-AcO-MET (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.
Technical Specifications
Why Researchers Choose 4-AcO-MET
🔬Serotonin Receptor Research
4-AcO-MET is valuable for studying serotonin receptor pharmacology, particularly 5-HT1A, 5-HT2A, and 5-HT2C receptor interactions. Its use as a reference standard enables precise analytical method validation.
🧬Neuropharmacology Studies
Research teams investigate 4-AcO-MET to understand tryptamine structure-activity relationships and their effects on neurotransmitter systems. This supports broader research into indolealkylamine pharmacology.
📊Analytical Chemistry
High-purity 4-AcO-MET serves as a crucial standard for developing detection methods in biological matrices, supporting forensic toxicology and quality control applications.
Research Applications
4-AcO-MET is commonly used in various scientific research contexts:
Important: All research applications are for in vitro and analytical purposes only. Not for human or veterinary use.
Chemical Properties
Solubility Data
Analytical Methods
External Chemical Databases
Safety & Hazard Information
Hazard Statements (H):
- •H302: Harmful if swallowed
- •H315: Causes skin irritation
- •H319: Causes serious eye irritation
- •H335: May cause respiratory irritation
Precautionary Statements (P):
- •P261: Avoid breathing dust/fume/gas/mist/vapors/spray
- •P264: Wash hands thoroughly after handling
- •P280: Wear protective gloves/protective clothing/eye protection/face protection
- •P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
Common Effects
Legal Status by Country
Legal for Research
Click any country to view detailed legal information and shipping regulations.
Frequently Asked Questions
Q:What is 4-AcO-MET used for in research?
4-AcO-MET is primarily used as an analytical reference standard in forensic toxicology, pharmacological research, quality control testing, and method development. It is NOT intended for human or veterinary use.
Q:How should 4-AcO-MET be stored?
Store 4-AcO-MET at -20°C in a dark, dry environment. Protect from light and moisture to maintain stability. When stored properly, research chemicals have a shelf life of approximately 2 years. Always use amber glass vials with proper sealing.
Q:Is 4-AcO-MET legal in my country?
Legal status varies by jurisdiction. 4-AcO-MET is legal for research purposes in several EU countries including Ireland, Italy, Spain as of 2026. Always verify current regulations in your specific location before ordering.
Q:What analytical methods are used to test 4-AcO-MET purity?
High-Performance Liquid Chromatography with UV detection (HPLC-UV) is the primary method for purity analysis. Additional confirmation methods include Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR) spectroscopy.
Q:What is the minimum purity guaranteed for EuroChems 4-AcO-MET?
All EuroChems 4-AcO-MET products are guaranteed to be ≥98% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) confirming purity specifications.
Related Research
Resources
Available in multiple languages upon request
Safety Notice
This compound is for research purposes only. Not for human consumption. Always use proper safety equipment and follow all applicable regulations.