Norflurazepam
Overview
Norflurazepam is a benzodiazepine metabolite studied for its pharmacological activity and GABAergic effects.
The history of Norflurazepam is rooted in benzodiazepine research that began with chlordiazepoxide's discovery in 1955 by Leo Sternbach at Hoffmann-La Roche. This breakthrough led to decades of research into GABAergic compounds and their therapeutic applications. Norflurazepam represents a modern continuation of this research tradition, emerging as scientists explored novel benzodiazepine analogs. Research into benzodiazepine derivatives has focused on understanding how structural modifications affect binding affinity for GABA-A receptor subtypes, duration of action, and pharmacological properties. Norflurazepam emerged as a compound of interest for studying these structure-function relationships and for use as an analytical reference standard. The compound has been characterized using advanced analytical techniques. Modern research applications of Norflurazepam include studies on GABAergic neurotransmission, receptor pharmacology, and the development of detection methods for novel benzodiazepines. The compound serves as a valuable tool in analytical chemistry and forensic toxicology, contributing to our understanding of GABA-A receptor modulation and anxiolytic mechanisms.
Norflurazepam acts as a positive allosteric modulator of GABA-A receptors, enhancing the effect of gamma-aminobutyric acid (GABA). This mechanism produces anxiolytic, sedative, and muscle-relaxant effects characteristic of benzodiazepine-class compounds.
Norflurazepam holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.
High-purity Norflurazepam (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.
Technical Specifications
Why Researchers Choose Norflurazepam
🔬GABA Receptor Research
Norflurazepam serves as a reference material for studying GABAergic neurotransmission and benzodiazepine receptor pharmacology. Its consistent purity enables reliable analytical method development.
🧬Anxiolytic Studies
Research teams investigate Norflurazepam to understand structure-activity relationships in benzodiazepine-like compounds and their modulation of GABA-A receptors.
📊Forensic Applications
High-purity Norflurazepam standards are essential for forensic toxicology laboratories developing detection methods for benzodiazepine analogs in biological samples.
Research Applications
Norflurazepam is commonly used in various scientific research contexts:
Important: All research applications are for in vitro and analytical purposes only. Not for human or veterinary use.
Chemical Properties
Solubility Data
Analytical Methods
External Chemical Databases
Safety & Hazard Information
Hazard Statements (H):
- •H302: Harmful if swallowed
- •H315: Causes skin irritation
- •H319: Causes serious eye irritation
- •H335: May cause respiratory irritation
Precautionary Statements (P):
- •P261: Avoid breathing dust/fume/gas/mist/vapors/spray
- •P264: Wash hands thoroughly after handling
- •P280: Wear protective gloves/protective clothing/eye protection/face protection
- •P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
Common Effects
Legal Status by Country
Legal for Research
Click any country to view detailed legal information and shipping regulations.
Frequently Asked Questions
Q:What is Norflurazepam used for in research?
Norflurazepam is primarily used as an analytical reference standard in forensic toxicology, pharmacological research, quality control testing, and method development. It is NOT intended for human or veterinary use.
Q:How should Norflurazepam be stored?
Store Norflurazepam at -20°C in a dark, dry environment. Protect from light and moisture to maintain stability. When stored properly, research chemicals have a shelf life of approximately 2 years. Always use amber glass vials with proper sealing.
Q:Is Norflurazepam legal in my country?
Legal status varies by jurisdiction. Norflurazepam is legal for research purposes in several EU countries including Ireland, Italy as of 2026. Always verify current regulations in your specific location before ordering.
Q:What analytical methods are used to test Norflurazepam purity?
High-Performance Liquid Chromatography with UV detection (HPLC-UV) is the primary method for purity analysis. Additional confirmation methods include Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR) spectroscopy.
Q:What is the minimum purity guaranteed for EuroChems Norflurazepam?
All EuroChems Norflurazepam products are guaranteed to be ≥98% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) confirming purity specifications.
Related Research
Resources
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Similar Compounds
Safety Notice
This compound is for research purposes only. Not for human consumption. Always use proper safety equipment and follow all applicable regulations.