Pagoclone

Pagoclone je analog benzodiazepinu používaný ve výzkumu modulace GABA-A receptorů. Tato sloučenina je studována pro své potenciální anxiolytické, sedativní a svalově relaxační vlastnosti.

The history of Pagoclone is rooted in benzodiazepine research that began with chlordiazepoxide's discovery in 1955 by Leo Sternbach at Hoffmann-La Roche. This breakthrough led to decades of research into GABAergic compounds and their therapeutic applications. Pagoclone represents a modern continuation of this research tradition, emerging as scientists explored novel benzodiazepine analogs. Research into benzodiazepine derivatives has focused on understanding how structural modifications affect binding affinity for GABA-A receptor subtypes, duration of action, and pharmacological properties. Pagoclone emerged as a compound of interest for studying these structure-function relationships and for use as an analytical reference standard. The compound has been characterized using advanced analytical techniques. Modern research applications of Pagoclone include studies on GABAergic neurotransmission, receptor pharmacology, and the development of detection methods for novel benzodiazepines. The compound serves as a valuable tool in analytical chemistry and forensic toxicology, contributing to our understanding of GABA-A receptor modulation and anxiolytic mechanisms.

Pagoclone acts as a positive allosteric modulator of GABA-A receptors, enhancing the effect of gamma-aminobutyric acid (GABA). This mechanism produces anxiolytic, sedative, and muscle-relaxant effects characteristic of benzodiazepine-class compounds.

Pagoclone holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.

High-purity Pagoclone (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.