3-HO-PCP
3-Hydroxyphencyclidine
Descripción General
3-HO-PCP es un disociativo de arilciclohexilamina utilizado en investigación de antagonismo del receptor NMDA. Este compuesto se estudia extensamente por sus propiedades anestésicas disociativas y aplicaciones neurofarmacológicas.
The history of 3-HO-PCP is linked to the development of dissociative anesthetics, beginning with the discovery of phencyclidine (PCP) in 1926 and ketamine in 1962. These compounds revealed that NMDA receptor antagonism could produce unique dissociative states distinct from other classes of psychoactive substances. 3-HO-PCP represents a continuation of research into this pharmacological mechanism. Research into arylcyclohexylamine and related dissociatives intensified in recent decades as scientists sought to understand the relationship between molecular structure and NMDA receptor binding affinity. 3-HO-PCP emerged as a compound of interest for studying dissociative mechanisms, anesthetic properties, and neuroprotective effects. The compound has been characterized using advanced analytical techniques including mass spectrometry and nuclear magnetic resonance spectroscopy. Modern research utilizing 3-HO-PCP focuses on understanding NMDA receptor pharmacology, glutamatergic neurotransmission, and potential therapeutic applications. The compound serves as a valuable reference standard in forensic toxicology and analytical chemistry, contributing to the development of detection methods for novel dissociatives in biological samples.
3-HO-PCP acts as an NMDA (N-methyl-D-aspartate) receptor antagonist, blocking glutamate neurotransmission. This mechanism produces characteristic dissociative effects and makes it valuable for studying glutamatergic system function.
3-HO-PCP holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.
High-purity 3-HO-PCP (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.
Especificaciones Técnicas
Por Qué los Investigadores Eligen 3-HO-PCP
🔬NMDA Receptor Studies
3-HO-PCP is utilized in research investigating NMDA receptor antagonism and its effects on glutamatergic neurotransmission. As a reference standard, it enables precise analytical quantification.
🧬Anesthesia Research
Researchers study 3-HO-PCP to understand dissociative anesthetic mechanisms and structure-activity relationships in arylcyclohexylamine compounds. This supports development of analytical detection methods.
📊Quality Assurance
Laboratories use high-purity 3-HO-PCP for method validation, equipment calibration, and developing screening protocols for dissociative compounds in various matrices.
Aplicaciones de Investigación
Descargo de Responsabilidad Importante: Este compuesto está destinado únicamente para investigación y fines analíticos. No para consumo humano.
Propiedades Químicas
Datos de Solubilidad
Métodos Analíticos
Bases de Datos Externas
Seguridad e Información de Peligros
Hazard Statements (H):
- •H302: Harmful if swallowed
- •H315: Causes skin irritation
- •H319: Causes serious eye irritation
- •H335: May cause respiratory irritation
Precautionary Statements (P):
- •P261: Avoid breathing dust/fume/gas/mist/vapors/spray
- •P264: Wash hands thoroughly after handling
- •P280: Wear protective gloves/protective clothing/eye protection/face protection
- •P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
Efectos Comunes
Estado Legal por País
Haga clic en cualquier país para ver información legal detallada y detalles de envío.
Preguntas Frecuentes
Q:What is 3-HO-PCP used for in research?
3-HO-PCP is primarily used as an analytical reference standard in forensic toxicology, pharmacological research, quality control testing, and method development. It is NOT intended for human or veterinary use.
Q:How should 3-HO-PCP be stored?
Store 3-HO-PCP at -20°C in a dark, dry environment. Protect from light and moisture to maintain stability. When stored properly, research chemicals have a shelf life of approximately 2 years. Always use amber glass vials with proper sealing.
Q:Is 3-HO-PCP legal in my country?
Legal status varies by jurisdiction. 3-HO-PCP is legal for research purposes in several EU countries including Ireland, Italy as of 2026. Always verify current regulations in your specific location before ordering.
Q:What analytical methods are used to test 3-HO-PCP purity?
High-Performance Liquid Chromatography with UV detection (HPLC-UV) is the primary method for purity analysis. Additional confirmation methods include Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR) spectroscopy.
Q:What is the minimum purity guaranteed for EuroChems 3-HO-PCP?
All EuroChems 3-HO-PCP products are guaranteed to be ≥98% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) confirming purity specifications.
Investigación Relacionada
Recursos
Aviso de Seguridad
Solo para fines de investigación. NO PARA CONSUMO HUMANO. Requiere Manipulación de Laboratorio Adecuada.