LSZ

LSZ es una lisergamida de investigación utilizada en estudios de farmacología del receptor de serotonina 5-HT2A. Este compuesto se utiliza ampliamente en química analítica como estándar de referencia y para investigación farmacológica que estudia las interacciones del receptor de serotonina.

The history of LSZ traces back to the research into lysergic acid derivatives that began in the mid-20th century. Following Albert Hofmann's groundbreaking discovery of LSD in 1943, researchers have continuously explored structural modifications to understand structure-activity relationships in ergoline compounds. LSZ emerged as part of this ongoing research into prodrugs and analogs of classical psychedelics. Research into LSZ gained momentum in the early 21st century as part of broader investigations into legal alternatives to controlled substances. Scientists studying serotonin 5-HT2A receptor pharmacology recognized the compound's value as a research tool for understanding how subtle structural modifications affect receptor binding affinity and functional activity. The compound has since become an important reference standard in analytical chemistry laboratories worldwide. Academic institutions and pharmaceutical research facilities have utilized LSZ to advance our understanding of psychedelic pharmacology, particularly regarding receptor selectivity, metabolic pathways, and structure-function relationships. This research has contributed valuable data to the fields of neuropharmacology and medicinal chemistry, helping researchers develop more selective therapeutic compounds.

As a lysergamide derivative, LSZ acts primarily on serotonin 5-HT2A receptors in the brain, producing characteristic psychedelic effects. Research suggests this compound binds to these receptors with high affinity, triggering downstream signaling cascades that modulate perception, cognition, and mood.

LSZ holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.

High-purity LSZ (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.