6-APB

6-APB is een empathogeen/entactogeen onderzoekschemicalie gebruikt in studies naar serotonine en dopamine afgifte. Deze verbinding is waardevol voor het bestuderen van monoamine neurotransmitter systemen.

The history of 6-APB is connected to research into entactogens and empathogens, a class of compounds that became prominent following the synthesis and characterization of MDMA in the early 20th century. Scientists investigating benzofuran and related compounds sought to understand how structural modifications affect serotonin and dopamine release mechanisms. 6-APB emerged as part of this systematic research. Research into novel empathogens intensified as chemists explored alternatives to classical entactogens, investigating compounds with potentially different pharmacological profiles. 6-APB became a subject of interest for its effects on monoamine neurotransmitter systems and potential applications in neuroscience research. The compound has been studied for its interactions with serotonin and dopamine transporters and receptors. Contemporary research utilizing 6-APB focuses on understanding empathogenic mechanisms, monoamine release pharmacology, and structure-activity relationships. The compound serves as an important analytical reference standard and contributes to research on social cognition, emotional processing, and neurotransmitter dynamics in laboratory settings.

6-APB acts primarily by promoting release of serotonin, dopamine, and norepinephrine while also inhibiting their reuptake. This dual mechanism produces characteristic empathogenic and entactogenic effects valuable for neuropharmacology research.

6-APB holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.

High-purity 6-APB (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.