Diphenidine
Przegląd
Diphenidine jest dysocjatywnąarylocykloheksylaminą używaną w badaniach antagonizmu receptora NMDA. Ten związek jest szeroko badany ze względu na swoje dysocjacyjne właściwości znieczulające i zastosowania neurofarmakologiczne.
The history of Diphenidine is linked to the development of dissociative anesthetics, beginning with the discovery of phencyclidine (PCP) in 1926 and ketamine in 1962. These compounds revealed that NMDA receptor antagonism could produce unique dissociative states distinct from other classes of psychoactive substances. Diphenidine represents a continuation of research into this pharmacological mechanism. Research into arylcyclohexylamine and related dissociatives intensified in recent decades as scientists sought to understand the relationship between molecular structure and NMDA receptor binding affinity. Diphenidine emerged as a compound of interest for studying dissociative mechanisms, anesthetic properties, and neuroprotective effects. The compound has been characterized using advanced analytical techniques including mass spectrometry and nuclear magnetic resonance spectroscopy. Modern research utilizing Diphenidine focuses on understanding NMDA receptor pharmacology, glutamatergic neurotransmission, and potential therapeutic applications. The compound serves as a valuable reference standard in forensic toxicology and analytical chemistry, contributing to the development of detection methods for novel dissociatives in biological samples.
Diphenidine acts as an NMDA (N-methyl-D-aspartate) receptor antagonist, blocking glutamate neurotransmission. This mechanism produces characteristic dissociative effects and makes it valuable for studying glutamatergic system function.
Diphenidine holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.
High-purity Diphenidine (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.
Specyfikacje Techniczne
Dlaczego Badacze Wybierają Diphenidine
🔬NMDA Receptor Studies
Diphenidine is utilized in research investigating NMDA receptor antagonism and its effects on glutamatergic neurotransmission. As a reference standard, it enables precise analytical quantification.
🧬Anesthesia Research
Researchers study Diphenidine to understand dissociative anesthetic mechanisms and structure-activity relationships in arylcyclohexylamine compounds. This supports development of analytical detection methods.
📊Quality Assurance
Laboratories use high-purity Diphenidine for method validation, equipment calibration, and developing screening protocols for dissociative compounds in various matrices.
Zastosowania badawcze
Ważne Zastrzeżenie: Ten związek jest przeznaczony wyłącznie do celów badawczych i analitycznych. Nie do spożycia przez ludzi.
Właściwości Chemiczne
Dane o Rozpuszczalności
Metody analityczne
Zewnętrzne Bazy Danych
Bezpieczeństwo i Informacje o Zagrożeniach
Hazard Statements (H):
- •H302: Harmful if swallowed
- •H315: Causes skin irritation
- •H319: Causes serious eye irritation
- •H335: May cause respiratory irritation
Precautionary Statements (P):
- •P261: Avoid breathing dust/fume/gas/mist/vapors/spray
- •P264: Wash hands thoroughly after handling
- •P280: Wear protective gloves/protective clothing/eye protection/face protection
- •P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
Częste Efekty
Status prawny według kraju
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Często zadawane pytania
Q:What is Diphenidine used for in research?
Diphenidine is primarily used as an analytical reference standard in forensic toxicology, pharmacological research, quality control testing, and method development. It is NOT intended for human or veterinary use.
Q:How should Diphenidine be stored?
Store Diphenidine at -20°C in a dark, dry environment. Protect from light and moisture to maintain stability. When stored properly, research chemicals have a shelf life of approximately 2 years. Always use amber glass vials with proper sealing.
Q:Is Diphenidine legal in my country?
Legal status varies by jurisdiction. Diphenidine is legal for research purposes in several EU countries including Ireland, Italy as of 2026. Always verify current regulations in your specific location before ordering.
Q:What analytical methods are used to test Diphenidine purity?
High-Performance Liquid Chromatography with UV detection (HPLC-UV) is the primary method for purity analysis. Additional confirmation methods include Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR) spectroscopy.
Q:What is the minimum purity guaranteed for EuroChems Diphenidine?
All EuroChems Diphenidine products are guaranteed to be ≥98% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) confirming purity specifications.
Powiązane Badania
Zasoby
Podobne Związki
Uwaga Bezpieczeństwa
Tylko do celów badawczych. NIE DO SPOŻYCIA PRZEZ LUDZI. Wymaga właściwej obsługi laboratoryjnej.