Professional Benzodiazepine & Thienodiazepine Research Reagents

The benzodiazepine class represents one of the most significant groups in neuropharmacological research, primarily studied for its role as a positive allosteric modulator (PAM) of the $\gamma$-aminobutyric acid type A ($GABA_{A}$) receptor. At Eurochems, we provide a specialized catalog of high-purity benzodiazepine analogs, including triazolo and thieno derivatives, engineered for precise structural-activity relationship (SAR) mapping and forensic toxicological profiling.

Molecular Diversity and Subunit Selectivity

Our collection covers a broad spectrum of the benzodiazepine pharmacophore. Researchers can source compounds varying in their substitution patterns at the $R_1$ through $R_7$ positions, which dictates their affinity for specific $GABA_{A}$ subunits ($\alpha 1, \alpha 2, \alpha 3$, and $\alpha 5$).

• Triazolobenzodiazepines: Featuring a fused triazole ring, these analogs often exhibit modified metabolic pathways, making them essential for comparative pharmacokinetic studies.

• Thienodiazepines: By replacing the core benzene ring with a thiophene ring, these compounds allow for the study of bioisosterism and its impact on receptor binding kinetics.

Analytical Integrity & HPLC Verification

In the field of analytical chemistry, the margin for error is zero. Every reagent in our Benzodiazepine category is subjected to:

1. High-Performance Liquid Chromatography (HPLC): To guarantee a minimum purity of 98%.

2. Mass Spectrometry (MS): To ensure a distinct and verifiable fragmentation pattern for forensic databases.

3. Stability Testing: Ensuring that our powders and pellets maintain their crystalline integrity under standardized laboratory conditions.

Note: All products within this category are intended strictly for forensic, laboratory, and analytical research. They are not for human or animal consumption.