Advanced Dissociative Research Chemicals: NMDA Receptor Antagonists

Our dissociative category features a premier selection of high-purity reagents specifically synthesized for the study of the glutamatergic system. These compounds primarily function as N-Methyl-D-Aspartate (NMDA) receptor antagonists, acting as uncompetitive channel blockers that inhibit the flow of ions through the NMDAR pore. This mechanism is the focus of extensive research regarding neuroplasticity, rapid-acting antidepressant effects, and the mapping of the arylcyclohexylamine pharmacophore.

The Arylcyclohexylamine & Diarylethylamine Classes

Eurochems provides high-fidelity reference standards across the two most significant structural classes of dissociatives:

• Arylcyclohexylamines: This classic family—which includes derivatives of ketamine and phencyclidine (PCP)—is defined by an amine-substituted cyclohexane ring attached to an aromatic ring. Researchers utilize these analogs to investigate how modifications at the $2’$ or $3’$ positions of the aryl ring affect binding affinity and metabolic stability.

• 1,2-Diarylethylamines: A more recent addition to the dissociative research landscape, this class (including compounds like diphenidine and methoxphenidine) offers a distinct scaffold for exploring non-competitive antagonism without the core cyclohexane ring structure.

Precision Standards for Analytical Research

Reliable data requires reliable reagents. Every compound in our dissociative collection is subjected to:

1. High-Performance Liquid Chromatography (HPLC): Ensuring a minimum purity of 98% to eliminate cross-reactivity in in vitro assays.

2. Solubility & Stability Profiling: Our Hydrochloride (HCl) salt forms are optimized for aqueous solubility, facilitating standardized volumetric dosing in laboratory environments.

3. MS/NMR Verification: Providing consistent spectroscopic signatures for accurate forensic identification and database matching.

Safety & Handling: All dissociative reagents are intended strictly for forensic, laboratory, and analytical research. They are not for human or animal consumption. Store in a cool, dry environment to maintain molecular integrity.