Advanced Lysergamide Research: Ergoline Derivatives & $5-HT_{2A}$ Ligands

Our Lysergamides category features an elite selection of high-purity ergoline derivatives, a structurally complex class of alkaloids recognized for their potent interactions with the serotonergic system. This family of compounds is defined by its tetracyclic ergoline core, serving as the primary scaffold for investigating $5-HT_{2A}$ receptor agonism, biased signaling, and neuroplasticity.

The Evolution of the Ergoline Scaffold

At Eurochems, we provide the latest analogs developed for analytical and forensic research. Our catalog explores three primary regions of molecular modification:

• N1-Substitution (Prodrugs): Includes analogs like 1P-LSD, 1cP-LSD, and 1V-LSD. These substitutions at the indole nitrogen are widely studied for their role as prodrugs, where the N1-acyl group is cleaved in vivo to reveal the parent molecule.

• N6-Alkyl Variations: Modifications at the N6 position, such as in AL-LAD or ETH-LAD, are utilized to study changes in binding affinity and potency, often resulting in distinct pharmacological profiles compared to the N6-methyl parent.

• C8-Amide Modifications: Investigating how changes to the diethylamide moiety—seen in compounds like LSZ—affect the fit within the receptor’s binding pocket.

Analytical Purity & Reference Integrity

In forensic and academic settings, the reliability of your data depends on the quality of your reagent. Every lysergamide in our collection is:

1. HPLC-Verified: Tested via High-Performance Liquid Chromatography to ensure a minimum purity of 98%.

2. Standardized Formats: Available in precision-laid blotters or 98%+ purity crystalline powder for custom dilution and GC-MS profiling.

3. Strictly Laboratory Grade: Intended for forensic, laboratory, and analytical research only. Not for human or animal consumption.