2-CMC

Chemical Name: 2-Chloromethcathinone

Molecular Formula: C10H12ClNO

Molecular Weight: 197.66 g/mol

2-Chloromethcathinone, commonly referred to as 2-CMC, is a synthetic cathinone compound notable for its structural similarity to other cathinones. Classified as a β-keto analogue, 2-CMC exists in the broader family of substituted cathinones, a group of chemicals known for their unique properties in research applications. 2-CMC has gained attention in analytical and scientific communities for its well-defined molecular characteristics and potential as a research chemical.

Chemical Structure and Properties

The molecular structure of 2-CMC features a chlorinated aromatic ring at the para-position, combined with a β-keto group located in the aliphatic chain. This specific structure influences the molecule’s chemical stability, solubility, and interaction with other chemical agents. The chlorination enhances its lipophilicity while maintaining precise physicochemical properties that make it applicable for targeted studies.

Key physical and chemical properties of 2-CMC include its crystalline form at standard conditions and its moderate water solubility. It exhibits a melting point range of approximately 147–150°C and is highly stable under controlled ambient conditions. The compound is soluble in common organic solvents such as ethanol, isopropanol, and acetonitrile, allowing for ease of preparation in laboratory procedures.

Applications in Research

2-CMC is widely sought after for research purposes, primarily in the fields of analytical chemistry and pharmacology. Laboratories employ 2-CMC for developing methodologies related to mass spectrometry (MS) and high-performance liquid chromatography (HPLC) due to its distinct ionization profile and chromatographic behavior. Researchers often use this compound as a reference standard or test analyte when optimizing detection systems that involve synthetic cathinones.

Pharmacological studies also regard 2-CMC as useful for its interaction with biochemical pathways linked to neurotransmitter systems. Investigations focusing on receptor binding assays, metabolism analyses, and pharmacokinetics benefit from the compound’s structural specificity and consistency. However, it is essential to note that 2-CMC is intended strictly for investigational purposes and is not approved for human or veterinary use.

Storage and Handling

Proper storage and handling protocols are critical for maintaining the integrity of 2-CMC in laboratory environments. The compound should be stored in a tightly sealed container, kept away from heat, moisture, and direct sunlight to prevent degradation. Ideal storage conditions range from 2°C to 8°C. Laboratory personnel handling 2-CMC must adhere to standard safety procedures, including the use of personal protective equipment such as gloves, goggles, and lab coats. Handling in a fume hood is recommended to avoid exposure to fine particulate matter.

Regulatory Considerations

It is paramount for institutions and researchers working with 2-CMC to comply with relevant regulatory requirements. While 2-CMC may not be classified under international control schedules in all jurisdictions, its production, distribution, and use in research must align with local and national regulations. Researchers should ensure that their acquisition and application of 2-CMC are consistent with institutional and legal guidelines, ensuring compliance with ethical practices.

Advantages for Analytical Studies

One of the primary advantages of 2-CMC in analytical research is its predictability and repeatability in experimental settings. With its defined chromatographic patterns and ion fragmentation profiles, it is well-suited for comparative studies involving similar synthetic cathinones or other β-keto analogs. Laboratories aiming to study emerging chemical entities in related categories frequently use 2-CMC to establish baselines or reference standards that further methodological precision.

Additionally, the compound’s stability and consistent reactivity under controlled conditions make it particularly advantageous for long-term studies. Whether exploring degradation pathways, thermal properties, or interaction with other compounds, researchers benefit from the reliability of 2-CMC in maintaining chemical integrity during tests.

Limitations and Considerations

Despite its utility, 2-CMC carries limitations that researchers must address appropriately. The compound requires careful calibration during experiments, as slight variations in preparation can alter observed results. Its specificity to certain experimental applications means that researchers must carefully define their study parameters when incorporating 2-CMC into projects.

Furthermore, toxicity and safety data regarding 2-CMC are limited, reinforcing the importance of strict observational protocols and containment measures. Regular waste management practices should be implemented to safely dispose of any remaining substance and prevent accidental exposure.

Available Forms and Purity

2-CMC is commercially available in various forms, including powder and crystalline variants. Laboratories and suppliers prioritize the delivery of high-purity (≥98%) grades to ensure optimal consistency in research applications. Certificate of Analysis (COA) documentation typically accompanies each batch to verify critical parameters such as purity, stability, and identification via spectral methods.

Summary

2-CMC is a versatile research chemical recognized for its stable and defined properties. Its applications span analytical chemistry, pharmacology, and materials science, where its cathinone structure enables targeted exploration. For institutions adhering to regulatory standards, 2-CMC offers robust potential as a model compound or analytical standard. However, all uses should remain firmly restricted to scientific contexts, as the compound is not intended for consumption or clinical applications. Safe handling and meticulous attention to storage conditions are essential to uphold its integrity during research and to guarantee the reliability of collected data.

By utilizing proper methodologies and maintaining compliance with ethical research standards, 2-CMC stands as a valuable tool for advancing chemical and pharmacological understanding in controlled environments.