4-AcO-DET Powder

4-Acetoxy-N,N-diethyltryptamine, commonly known as 4-AcO-DET, is a synthetic tryptamine belonging to the broader family of substituted tryptamines. This substance is primarily of interest for research and analytical purposes due to its structural relation to both psilocybin and other serotoninergic compounds. It is offered in powdered form, providing precise dosing measures for laboratory applications.

Chemical Composition and Structure

The molecular formula of 4-AcO-DET is C14H20N2O2, with a molecular weight of 248.32 g/mol. It is chemically defined as N,N-diethyl-4-acetoxytryptamine, featuring an indole ring substituted at the R4 position with an acetoxy moiety and at the amine group with two ethyl substituents. This acetoxy group serves as a modification of the corresponding hydroxy group in its structurally similar analogue, 4-HO-DET.

4-AcO-DET is classified as a prodrug, meaning that upon metabolic processing, it is believed to convert into 4-HO-DET (4-hydroxy-N,N-diethyltryptamine), the active metabolite. Structurally, 4-AcO-DET bears similarities to naturally occurring psychedelic compounds and has been hypothesized as an analog of psilocybin, albeit with a distinctive pharmacological profile.

Presentation and Packaging

4-AcO-DET is provided in a high-purity powdered form intended exclusively for controlled laboratory settings. The substance is meticulously synthesized and subjected to rigorous quality assessments to ensure consistency and chemical integrity.

Applications

4-AcO-DET powder is primarily used in research settings for the study of tryptamine derivatives and their interaction with serotonin receptors, specifically the 5-HT2A receptor subtype. Researchers have explored its pharmacodynamics and pharmacokinetics to better understand its role as a prodrug and potential activity in serotonergic systems. Additionally, it serves as a point of comparison for studying structure-activity relationships (SAR) in related tryptamine analogues.

It is important to note that 4-AcO-DET is not intended for human consumption or therapeutic usage. It is strictly sold for in vitro experimentation or other forms of non-human research, provided such activities comply with local, state, and federal laws.

Handling and Storage

Safe handling practices are critical when working with 4-AcO-DET. It should only be manipulated within a controlled environment following proper laboratory safety protocols, such as wearing gloves, goggles, and utilizing a fume hood when necessary. Direct contact with skin, ingestion, or inhalation must be strictly avoided.

For optimal stability, the substance should be stored in a cool, dry location, away from direct light and moisture. A temperature-controlled environment between 2-8°C is recommended for preventing potential degradation of the material over time. Proper storage ensures the longevity and reliability of the compound during research activities.

Safety Considerations

While specific toxicological data on 4-AcO-DET is limited due to its research chemical status, it is important to treat it with the same caution as other similar chemical substances. Standard safety references such as Material Safety Data Sheets (MSDS) should be consulted prior to use, offering detailed guidance on hazardous properties, first aid measures, and chemical reactivity. Additionally, laboratories should have emergency safety equipment, such as eyewash stations and spill containment kits, readily available.

Researchers are advised to conduct a thorough risk assessment before undertaking any experimentation. Adhering to responsible research practices not only ensures researcher safety but also mitigates the risk of inaccuracies or loss of material integrity.

Regulatory Status

The regulatory classification of 4-AcO-DET varies geographically. While it remains unscheduled in several jurisdictions, its status may be restricted or subject to additional legislative measures in other regions. Researchers and institutions must ensure compliance with all applicable laws and regulations related to its acquisition, usage, and recordkeeping.

Due to its potential classification as a controlled substance analogue, procurement and utilization should include consultation with regulatory bodies or legal experts to ensure transparency within permissible research parameters.

Disclaimer

This technical document is intended for informational purposes specific to qualified researchers and analytical laboratories. 4-AcO-DET is supplied under the condition that it will not be used for purposes other than lawful research as defined by applicable laws. Any misuse, diversion, or application outside of an approved research framework is neither endorsed nor supported by the supplier.

By understanding and adhering to these guidelines, laboratories can effectively integrate 4-AcO-DET into their research repertoire, contributing valuable insights into the chemistry and pharmacological profiles of substituted tryptamines.