4-HO-EPT Powder

4-HO-EPT (4-hydroxy-N-ethyl-N-propyltryptamine) is a synthetic tryptamine compound belonging to the broader class of hydroxylated tryptamines. Its molecular structure incorporates a hydroxy group at the 4-position of the indole ring, a feature shared with other similar tryptamines, making it a compound of particular interest for researchers studying structure-activity relationships and novel tryptamine functionalities.

Chemical Composition and Properties

• Chemical Name: 4-Hydroxy-N-ethyl-N-propyltryptamine
• Molecular Formula: C13H20N2O
• Molecular Weight: 220.31 g/mol
• Form: Fine crystalline powder
• Purity: ≥98% (HPLC-verified)

4-HO-EPT is a white-to-off-white crystalline powder, showcasing excellent solubility in ethanol, dimethyl sulfoxide (DMSO), and similar polar solvents. It is relatively stable under proper storage conditions, retaining its integrity when stored in a cool, dry place free from light exposure and moisture.

Potential Areas of Research

The structure of 4-HO-EPT forms a fascinating middle ground between simpler hydroxylated tryptamines such as 4-HO-DMT (psilocin) and more complex derivatives. Researchers investigating receptor binding affinities, metabolic pathways, and pharmacological profiles of tryptamines may find this compound valuable for comparative studies. Specifically, the compound’s unique ethyl and propyl substitutions on the nitrogen atom add a layer of complexity that merits detailed exploration in terms of its steric and electronic effects on bioactivity.

Possible applications in research include, but are not limited to:

1. Receptor Binding Analysis

Researchers may explore how 4-HO-EPT interacts with serotonin receptor subtypes, particularly the 5-HT2A and 5-HT1A receptors. Differences in binding affinity compared to other compounds within the 4-HO-tryptamine class can provide insights into receptor selectivity and activation mechanisms.

2. Pharmacokinetics and Metabolism

Studying the metabolic pathways of 4-HO-EPT can aid in understanding how the hydroxy group and its N-substitutions affect enzymatic processing within biological systems. Such studies can contribute to understanding how tryptamine derivatives are absorbed, distributed, metabolized, and excreted.

3. Structure-Activity Relationships (SAR)

The ethyl and propyl substitutions on the amine group lend themselves to SAR studies, whereby researchers can identify how these groups influence receptor interactions and overall potency. This is significant in elucidating how minor modifications in molecular structure influence behavioral or biochemical outcomes.

4. Comparative Neurochemical Analysis

Comparative studies between 4-HO-EPT and other 4-HO-tryptamines such as 4-HO-DMT or 4-HO-MET can help delineate the functional implications of varying alkyl chain lengths on the ligand’s performance.

Handling and Safety

4-HO-EPT is intended solely for laboratory research and analytical purposes. It is not approved for human or veterinary consumption. Researchers handling this compound should adhere to standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Direct skin contact, inhalation, or accidental ingestion must be avoided.

• Storage Conditions

Store the powder in a tightly sealed container. Ideal storage conditions include a temperature range of 2-8°C with minimal exposure to air, light, and humidity, as such factors may degrade the compound.

• Stability Considerations

4-HO-EPT should be handled in tightly controlled environments to prevent contamination or degradation. Labs are advised to aliquot the compound into smaller quantities to minimize repeated exposure.

Applications Beyond Biochemical Research

While the primary focus of 4-HO-EPT remains biochemical and pharmacological research, its physicochemical properties also position it as a candidate for the development of biochemical models that assess ligand-receptor interactions. Computational chemists may find this compound useful for generating predictive models that simulate its molecular interactions in virtual environments.

Technical Specifications

• CAS Number: (Not currently assigned)
• Melting Point: Approx. 195-198°C (decomposition)
• Solubility Profile:
• • Soluble in polar organic solvents.
  • Limited solubility in non-polar solvents.
• Appearance: Fine white to off-white crystalline powder.
• Packaging:
• • Available in secure, airtight containers to preserve compound integrity.

Disclaimer

This product is sold strictly for laboratory and research purposes. It is not intended for human consumption or diagnostic, therapeutic, or medical applications. Compliance with all local, state, and federal laws and regulations is the responsibility of the purchaser.

Researchers looking to advance their understanding of tryptamine pharmacology or synthetic chemistry will find 4-HO-EPT a versatile and reliable compound for experimental applications. When used responsibly and within the boundaries of ethical research, 4-HO-EPT has the potential to significantly contribute to cutting-edge biochemical investigations.

This detailed product description ensures researchers have all technical data and context required for effective utilization of 4-HO-EPT in their studies. Always handle this compound with care and in compliance with institutional safety guidelines.