4-MPD

4-MPD, or 4′-Methylpropiophenone, is a versatile chemical compound with significant applications across various industries. Its molecular structure consists of a phenyl ring attached to a propiophenone moiety, with a methyl group at the para position. This compound falls under the category of ketones, offering unique chemical properties that contribute to its functionality in multiple processes and formulations.

Chemical Properties and Specifications

4-MPD is characterized by its precise molecular formula, C10H12O, with a molar mass of approximately 148.20 g/mol. It typically appears as a colorless or pale yellow liquid, ensuring ease of handling and application. The compound has a boiling point ranging between 238–240°C under standard atmospheric conditions, and it is sparingly soluble in water. However, it demonstrates excellent solubility in organic solvents such as ethanol and acetone, enhancing its compatibility in laboratory and industrial settings.

4-MPD exhibits remarkable stability when stored under recommended conditions, including a cool and dry environment, away from direct sunlight or moisture. This stability ensures a long shelf life and reduces the likelihood of degradation during storage and transport. The compound’s reactivity profile makes it a popular choice in controlled chemical reactions, where its functional ketone group contributes as a key reactive intermediate.

Applications in Industry

4-MPD’s primary use lies in its role as an intermediate in organic synthesis. It serves as a building block for the production of various fine chemicals, pharmaceuticals, and agrochemical products. The compound’s ketone group offers high reactivity, making it valuable in acylation, alkylation, and other synthetic reactions. Researchers and manufacturers widely utilize it in laboratory-scale experiments and large-scale industrial operations.

1. Pharmaceuticals

4-MPD contributes to the development of active pharmaceutical ingredients (APIs) and other medicinal compounds. Its chemical properties enable it to undergo transformations that yield products with therapeutic significance. Chemists utilize 4-MPD in producing analgesics, sedatives, and other classes of medications where a propiophenone derivative may serve as a precursor.

2. Fine Chemicals

Beyond pharmaceuticals, 4-MPD finds application in the fine chemical industry. It is part of the synthesis of specialty chemicals used in fragrances, dyes, and polymer additives. Its structural versatility allows it to act as a precursor for designing tailored compounds with distinct functional properties.

3. Research and Development

Laboratories involved in chemical research leverage 4-MPD as a reagent or starting material for novel compounds. Its predictable reactivity and compatibility with various reaction conditions make it an essential resource for exploratory studies in organic chemistry.

Guidelines for Handling and Safety

Due to its chemical nature, proper handling of 4-MPD is crucial to ensure the safety of personnel and the environment. The material should be handled with appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. Working in a well-ventilated area or using a fume hood is strongly recommended to reduce exposure to fumes and vapors.

Although 4-MPD has a relatively low toxicity profile, ingestion, inhalation, or direct skin contact can be harmful and should be avoided. If exposure occurs, appropriate first-aid measures must be taken, such as rinsing the affected area thoroughly in case of skin or eye contact or seeking medical attention if ingested.

Guidelines for disposal must comply with local, regional, and international regulations. Leftover material or waste should never be disposed of in household or industrial drains but instead handled through certified waste management systems.

Packaging and Availability

Manufacturers supply 4-MPD in various quantities to meet the demand of small laboratories and large-scale industrial clients. It is typically packaged in airtight containers made of glass or high-density polyethylene (HDPE) to prevent contamination and ensure product integrity. Custom packaging solutions may be available based on the purchaser’s specific requirements.

Regulatory Compliance

4-MPD is subject to regulatory oversight depending on its intended use and the region in which it is being handled. Users must ensure compliance with relevant directives, such as EU REACH regulations, the U.S. Toxic Substances Control Act (TSCA), or other applicable chemical safety guidelines. Understanding the regulatory landscape is essential before purchasing and utilizing 4-MPD to avoid potential legal and operational complications.

Storage Recommendations

To maintain its integrity, 4-MPD should be stored in a tightly sealed container within a cool, dry, and well-ventilated area. Avoid exposure to heat sources, open flames, and moisture, as these factors may promote degradation. Proper labeling of containers is critical for traceability and accident prevention, especially in environments where multiple chemicals are stored.

Summary

4-MPD is a highly functional chemical compound with a wide range of applications, particularly in the pharmaceutical and fine chemical industries. Its stability, reactivity, and compatibility with various solvents make it an indispensable tool for organic synthesis and research. Proper handling, storage, and adherence to safety measures are crucial to maximizing its utility while minimizing risks. Whether for small-scale research or large-scale production, 4-MPD provides a reliable and efficient solution for advancing chemical innovations.