7-AFF

7-Amino-4-(trifluoromethyl)quinoline, commonly abbreviated as 7-AFF, is a high-purity chemical compound widely utilized in research and industrial applications. With the molecular formula C10H7F3N2 and a molecular weight of 212.17 g/mol, this compound is distinguished by its unique trifluoromethyl group and quinoline core structure. These structural properties make 7-AFF a versatile intermediate and reagent in diverse chemical synthesis pathways.

Chemical Characteristics and Attributes

7-AFF is a pale yellow to off-white crystalline solid under standard conditions. It exhibits excellent thermal stability and has a high melting point in the range of 120°C to 130°C, depending on the purity. Its chemical structure includes a trifluoromethyl group, which imparts hydrophobic and electron-withdrawing characteristics that are ideal for enhancing the reactivity and selectivity of the compound in various reactions. The amino group at the seventh position of the quinoline ring further allows 7-AFF to act as a key building block for a wide range of derivatives.

The trifluoromethyl group enhances the compound’s properties in terms of solubility, metabolic stability, and bioactivity, while the quinoline framework serves as a scaffold for designing pharmaceuticals, agrochemicals, and dyes. The precise positioning of functional groups ensures high specificity in chemical reactions, making it a sought-after compound in laboratories and industrial processes.

Applications in Research and Industry

7-AFF is prominently used in organic synthesis as a precursor for the development of functional molecules. Its versatility allows it to be employed in the design of advanced materials and active pharmaceutical ingredients (APIs). Below are some of the key applications of 7-AFF:

1. Pharmaceutical Research

The quinoline moiety present in 7-AFF is a well-known scaffold in medicinal chemistry, serving as a foundation for the development of antifungal, antimalarial, and anticancer drugs. The amino group enables further chemical functionalization, enabling researchers to synthesize derivatives targeting specific biological pathways. The trifluoromethyl group’s presence improves the drug-like traits of synthesized compounds, including enhanced membrane permeability and metabolic resistance.

2. Material Science

7-AFF is used in the fabrication of optoelectronic materials and fluorescent probes. The compound’s intrinsic fluorescence properties, due to the quinoline backbone, make it a candidate for developing sensors and imaging agents. For example, 7-AFF can be incorporated into fluorescence-based detection systems to identify biological and chemical analytes with high sensitivity.

3. Agrochemical Development

Agrochemical formulations often require compounds with enhanced stability and bioavailability. 7-AFF, with its electron-withdrawing trifluoromethyl group, plays a role in the development of herbicides, pesticides, and fungicides. The compound’s properties enable active ingredients to have prolonged effectiveness and improved interaction profiles with agricultural targets.

4. Chemical Research

Being a versatile nitrogen-containing heterocyclic compound, 7-AFF serves as a research reagent for synthesizing novel organofluorine compounds. Researchers frequently explore its reactivity to discover new reaction mechanisms and pathways in fluorinated compound chemistry, further paving the way for innovation.

Storage and Handling Guidelines

Handling 7-AFF requires adherence to standard chemical safety protocols as it may pose health or environmental hazards if used improperly. Store the compound in a tightly sealed container, away from sources of moisture, direct sunlight, and oxidizing agents. It should be kept in a cool, dry location where the temperature does not exceed standard ambient conditions.

Proper personal protective equipment (PPE), including gloves, lab coats, and safety goggles, should be employed during handling. If accidental contact or exposure occurs, follow the chemical safety data sheet (SDS) guidelines for first aid and spill management.

Quality and Purity

7-AFF is generally available in high-purity grades, often exceeding 98%, which ensures reliable performance across applications. Analytical methods such as HPLC and NMR spectroscopy are employed for quality assurance to confirm the compound’s structural and chemical integrity.

Packaging and Availability

7-AFF is typically supplied in quantities ranging from grams to kilograms to accommodate both laboratory-scale research and industrial-scale production. Packaging is designed to prevent contamination and ensure long-term stability during storage and transportation. Custom packaging options are available upon request for specialized applications.

Summary of Key Features

• Chemical Name: 7-Amino-4-(trifluoromethyl)quinoline
• Molecular Formula: C10H7F3N2
• Molecular Weight: 212.17 g/mol
• Appearance: Pale yellow to off-white crystalline solid
• Melting Point: 120°C – 130°C
• Applications: Pharmaceutical synthesis, material science, agrochemical development, and chemical research
• Purity: ≥98% (typical)

Summary

7-AFF (7-Amino-4-(trifluoromethyl)quinoline) offers exceptional versatility across numerous fields, including drug development, agricultural enhancements, and cutting-edge materials research. Its well-defined chemical properties and high-purity standards make it a preferred choice for scientists and industrial chemists. By incorporating 7-AFF into research and production pipelines, innovators can unlock new possibilities in chemical and material advancements.