Isopropylphenidate HCL Powder

Isopropylphenidate HCL (Hydrochloride) Powder is a research chemical known for its stimulant properties and structural similarity to methylphenidate, a compound commonly used in medical applications for managing attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Isopropylphenidate (IPH) is a phenethylamine and piperidine derivative and is classified as a norepinephrine–dopamine reuptake inhibitor (NDRI). This technical description provides an in-depth overview of its properties, applications, and handling requirements.

Chemical Properties

• Chemical Name: Isopropylphenidate Hydrochloride
• Chemical Formula: C15H21ClNO2
• Molecular Weight: 283.79 g/mol
• Purity: ≥ 98%
• Physical State: Powder
• Color: White to off-white crystalline
• Solubility: Soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), as well as in water at appropriate concentrations.

Isopropylphenidate HCL is a stable compound when stored correctly. It exhibits low hygroscopicity, ensuring its extended usability in controlled laboratory environments. The compound is differentiated by the substitution of an isopropyl ester functional group in place of the methyl ester group found in methylphenidate.

Mechanism of Action

Isopropylphenidate primarily affects the central nervous system by inhibiting the reuptake of dopamine and norepinephrine neurotransmitters. It binds to the transport proteins responsible for dopamine and norepinephrine reuptake, thereby increasing the levels of these neurotransmitters in the synaptic cleft. This mechanism enhances neural activity associated with alertness, focus, and energy. Compared to methylphenidate, isopropylphenidate demonstrates a higher affinity for dopamine transporters, which may result in a different pharmacological profile.

Applications

Isopropylphenidate HCL Powder is intended strictly for research and analytical purposes. It is commonly utilized in laboratories and research institutions to study:

1. Neurochemical Interactions: Investigating its binding affinity to dopamine and norepinephrine transporters and its role in neurotransmitter modulation.
2. Psychostimulant Properties: Understanding how IPH compares to other stimulants in terms of efficacy, potency, and duration of action.
3. Pharmacological Modeling: Evaluating its potential as a model compound for the development of new therapeutic agents targeting ADHD or other neurological disorders.
4. Structure-Activity Relationship (SAR) Studies: Exploring the impact of structural modifications on pharmacological activity, efficacy, and side effect profiles.

Handling and Storage

Proper handling and storage of Isopropylphenidate HCL Powder are essential to maintain its integrity and ensure safety in the research environment:

• Storage Conditions: Store the powder in a cool, dry, and well-ventilated area. Optimal storage temperature is between 2°C and 8°C. Protect the substance from moisture and direct sunlight to prevent degradation.
• Handling Precautions: Use laboratory-grade personal protective equipment (PPE), including gloves, lab coats, and protective eyewear, when working with the compound. Ensure any handling occurs in a well-ventilated area, preferably within a fume hood.
• Stability: The compound is stable under standard laboratory conditions but should not be exposed to heat or open flame. Prolonged exposure to air or water can affect its purity and potency.

Legal and Safety Considerations

Isopropylphenidate HCL Powder is intended solely for qualified researchers, chemical analysts, and laboratories. It is not approved for human or veterinary use and should never be consumed, injected, or used outside of controlled experimental settings. Researchers must verify the legality of obtaining, possessing, and utilizing this compound in their jurisdiction, as its status may vary depending on regional regulations.

• Safety Hazards: This chemical is classified as potentially hazardous. Avoid inhalation, ingestion, or contact with skin and eyes. Use appropriate containment systems to minimize exposure risks.
• Disposal Instructions: Any waste material containing Isopropylphenidate HCL must be disposed of in compliance with local, state, and federal environmental guidelines.

Advantages in Research Contexts

Isopropylphenidate HCL offers several advantages for research use, including:

1. High Potency: Its strong binding affinity makes it a valuable tool for studies related to dopaminergic and noradrenergic systems.
2. Distinct Kinetics: Provides researchers with unique insights into the impact of ester group modifications on stimulant activity and duration.
3. Purity and Consistency: The high-purity formulation ensures optimal reliability for experimental reproducibility.

Limitations and Precautions

While Isopropylphenidate HCL is a robust and valuable research tool, it must be employed responsibly under strict guidelines. Misuse or deviation from certified research applications can pose ethical, legal, and safety concerns. Additionally, due to its stimulant effects, researchers should exercise heightened vigilance to avoid accidental exposure.

Summary

Isopropylphenidate HCL Powder is a prominent research chemical, offering applications in neurochemical studies, psychostimulant modeling, and pharmacological exploration. Its high purity, stability, and precise mechanism of action make it an essential tool for cutting-edge laboratory investigation. However, strict adherence to safety protocols and ethical guidelines is critical for its appropriate usage. By upholding these standards, researchers can derive maximum value from this compound while ensuring safety and compliance in their respective studies.