Escaline

Escaline este o fenetilamină substituită utilizată în cercetarea farmacologiei receptorilor de serotonină 5-HT2A. Acest compus este utilizat pe scară largă în studii ale relațiilor structură-activitate ale psihedelic elor.

The history of Escaline traces back to the extensive research into substituted phenethylamines pioneered by Alexander Shulgin and others. Beginning with mescaline's isolation from peyote cacti and expanding to thousands of synthetic analogs, this research has revealed how structural modifications dramatically affect pharmacological properties. Escaline represents a continuation of this systematic exploration. Research into phenethylamine derivatives has focused on understanding structure-activity relationships at serotonin receptors, particularly 5-HT2A and 5-HT2C subtypes. Escaline emerged as a compound of interest for studying how specific substituents affect receptor binding affinity, selectivity, and functional activity. The compound has been characterized using sophisticated analytical methods including high-resolution mass spectrometry and NMR spectroscopy. Modern research applications of Escaline include investigations into psychedelic pharmacology, receptor mechanisms, and the development of analytical detection methods. The compound serves as a valuable reference standard in research laboratories and contributes to our understanding of serotonin receptor pharmacology and psychedelic mechanisms of action.

Escaline acts primarily as a serotonin 5-HT2A receptor agonist, producing characteristic psychedelic effects. Research suggests phenethylamines bind to these receptors with varying affinities, making them valuable for studying structure-function relationships.

Escaline holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.

High-purity Escaline (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.