Ketamine
Prehľad
Ketamine je disociatívny arylcyklohexylamin používaný vo výskume antagonizmu NMDA receptorov. Táto zlúčenina je rozsiahle študovaná pre svoje disociatívne anestetické vlastnosti a neurofarmakologické aplikácie.
The history of Ketamine is linked to the development of dissociative anesthetics, beginning with the discovery of phencyclidine (PCP) in 1926 and ketamine in 1962. These compounds revealed that NMDA receptor antagonism could produce unique dissociative states distinct from other classes of psychoactive substances. Ketamine represents a continuation of research into this pharmacological mechanism. Research into arylcyclohexylamine and related dissociatives intensified in recent decades as scientists sought to understand the relationship between molecular structure and NMDA receptor binding affinity. Ketamine emerged as a compound of interest for studying dissociative mechanisms, anesthetic properties, and neuroprotective effects. The compound has been characterized using advanced analytical techniques including mass spectrometry and nuclear magnetic resonance spectroscopy. Modern research utilizing Ketamine focuses on understanding NMDA receptor pharmacology, glutamatergic neurotransmission, and potential therapeutic applications. The compound serves as a valuable reference standard in forensic toxicology and analytical chemistry, contributing to the development of detection methods for novel dissociatives in biological samples.
Ketamine acts as an NMDA (N-methyl-D-aspartate) receptor antagonist, blocking glutamate neurotransmission. This mechanism produces characteristic dissociative effects and makes it valuable for studying glutamatergic system function.
Ketamine holds significant value in scientific research due to its well-characterized properties and legal accessibility in several jurisdictions. This enables comprehensive pharmacological studies and analytical method development.
High-purity Ketamine (≥98% by HPLC) serves as a crucial reference standard in research laboratories, quality control testing, and academic research settings. Its consistent quality makes it ideal for method development and validation.
Technické Špecifikácie
Prečo si Výskumníci Vyberajú Ketamine
🔬NMDA Receptor Studies
Ketamine is utilized in research investigating NMDA receptor antagonism and its effects on glutamatergic neurotransmission. As a reference standard, it enables precise analytical quantification.
🧬Anesthesia Research
Researchers study Ketamine to understand dissociative anesthetic mechanisms and structure-activity relationships in arylcyclohexylamine compounds. This supports development of analytical detection methods.
📊Quality Assurance
Laboratories use high-purity Ketamine for method validation, equipment calibration, and developing screening protocols for dissociative compounds in various matrices.
Výskumné aplikácie
Dôležité Upozornenie: Táto zlúčenina je určená len na výskumné a analytické účely. Nie je určená na ľudskú spotrebu.
Chemické Vlastnosti
Údaje o Rozpustnosti
Analytické metódy
Externé Databázy
Bezpečnosť a Informácie o Nebezpečenstve
Hazard Statements (H):
- •H302: Harmful if swallowed
- •H315: Causes skin irritation
- •H319: Causes serious eye irritation
- •H335: May cause respiratory irritation
Precautionary Statements (P):
- •P261: Avoid breathing dust/fume/gas/mist/vapors/spray
- •P264: Wash hands thoroughly after handling
- •P280: Wear protective gloves/protective clothing/eye protection/face protection
- •P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
Bežné Účinky
Právny status podľa krajiny
Kontrolovaná Látka
Kliknite na krajinu pre zobrazenie podrobných právnych informácií a podrobností o doručení.
Často kladené otázky
Q:What is Ketamine used for in research?
Ketamine is primarily used as an analytical reference standard in forensic toxicology, pharmacological research, quality control testing, and method development. It is NOT intended for human or veterinary use.
Q:How should Ketamine be stored?
Store Ketamine at -20°C in a dark, dry environment. Protect from light and moisture to maintain stability. When stored properly, research chemicals have a shelf life of approximately 2 years. Always use amber glass vials with proper sealing.
Q:What analytical methods are used to test Ketamine purity?
High-Performance Liquid Chromatography with UV detection (HPLC-UV) is the primary method for purity analysis. Additional confirmation methods include Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS/MS), and Nuclear Magnetic Resonance (NMR) spectroscopy.
Q:What is the minimum purity guaranteed for EuroChems Ketamine?
All EuroChems Ketamine products are guaranteed to be ≥98% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) confirming purity specifications.
Súvisiaci Výskum
Zdroje
Bezpečnostné Upozornenie
Len na výskumné účely. NIE JE URČENÉ NA ĽUDSKÚ SPOTREBU. Vyžaduje správnu laboratórnu manipuláciu.