Compounds / Category Guide

Phenethylamines

Research chemical guide: effects, safety, and compound information

What are Phenethylamines?

Phenethylamines are a large class of compounds that include many psychedelics and entactogens. Research phenethylamines are studied for their effects on serotonin receptors and structure-activity relationships.

Common Effects

Visual hallucinations
Enhanced colors and patterns
Altered perception
Euphoria
Empathy

Safety Information

Highly potent compounds. Many have very long durations (12-30 hours). Always verify dosing.

Phenethylamines in Our Database (27 compounds)

2C-B

4-Bromo-2,5-dimethoxyphenethylamine

2C-B is a phenethylamine used extensively in pharmacological research on serotonin 5-HT2 receptor mechanisms and psychedelic effects.

Duration: 4-8 hours
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2C-B-FLY

8-Bromo-2,3,6,7-benzo-dihydro-difuran-ethylamine

2C-B-FLY is a benzodifuran phenethylamine studied for structure-activity relationships in psychedelic research.

Duration: 6-12 hours
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2C-C

4-Chloro-2,5-dimethoxyphenethylamine

2C-C is a phenethylamine compound used in research on 5-HT2A receptor activation and psychedelic pharmacology.

Duration: 4-8 hours
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2C-D

2,5-Dimethoxy-4-methylphenethylamine

2C-D is a phenethylamine used in psychopharmacology research, particularly for studying dose-response relationships in psychedelics.

Duration: 4-6 hours
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2C-E

4-Ethyl-2,5-dimethoxyphenethylamine

2C-E is a phenethylamine compound studied for its effects on serotonin receptors and psychedelic intensity dose curves.

Duration: 6-10 hours
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2C-I

4-Iodo-2,5-dimethoxyphenethylamine

2C-I is a potent phenethylamine used in research on halogenated psychedelic compounds and receptor binding affinity.

Duration: 6-10 hours
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2C-P

4-Propyl-2,5-dimethoxyphenethylamine

2C-P is a phenethylamine with an extended duration, used in long-acting psychedelic pharmacology research.

Duration: 10-20 hours
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25I-NBOMe

2C-I-NBOMe

25I-NBOMe is a highly potent 5-HT2A receptor agonist used in research on psychedelic receptor pharmacology and structure-activity relationships.

Duration: 6-10 hours
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25B-NBOMe

2C-B-NBOMe

25B-NBOMe is an N-benzyl phenethylamine used in research on ultra-potent 5-HT2A receptor agonists. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 6-10 hours
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25C-NBOMe

2C-C-NBOMe

25C-NBOMe is a phenethylamine derivative used in studying N-benzyl substitution effects on serotonin receptor pharmacology.

Duration: 6-10 hours
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DOI

2,5-Dimethoxy-4-iodoamphetamine

DOI is a substituted amphetamine used in research on 5-HT2A receptor pharmacology and long-acting psychedelics.

Duration: 16-30 hours
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DOC

2,5-Dimethoxy-4-chloroamphetamine

DOC is an amphetamine-class psychedelic used in long-duration serotonin receptor research. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 12-24 hours
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DOB

2,5-Dimethoxy-4-bromoamphetamine

DOB is a substituted amphetamine studied for its potent 5-HT2A receptor agonist properties and extended duration.

Duration: 18-30 hours
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Mescaline

3,4,5-Trimethoxyphenethylamine

Mescaline is a naturally occurring phenethylamine used extensively in research on classical psychedelic mechanisms and serotonin pharmacology.

Duration: 8-14 hours
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2C-T-2

2,5-Dimethoxy-4-ethylthiophenethylamine

2C-T-2 is a thiophenethylamine studied for sulfur-substituted psychedelic pharmacology. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 6-10 hours
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2C-T-7

2,5-Dimethoxy-4-propylthiophenethylamine

2C-T-7 is a substituted phenethylamine used in research on thio-substituted psychedelics. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 8-15 hours
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2C-T-4

2,5-Dimethoxy-4-isopropylthiophenethylamine

2C-T-4 is a thiophenethylamine studied for structure-activity relationships in psychedelic research.

Duration: 8-12 hours
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25D-NBOMe

25D-NBOMe is an N-benzyl phenethylamine used in research on ultra-potent 5-HT2A agonists. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 6-10 hours
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25E-NBOMe

25E-NBOMe is an NBOMe compound studied for high-potency serotonin receptor pharmacology. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 6-10 hours
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DOM

2,5-Dimethoxy-4-methylamphetamine

DOM is a substituted amphetamine used extensively in research on long-acting psychedelics and 5-HT2A receptor pharmacology.

Duration: 14-24 hours
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Escaline

3,5-Dimethoxy-4-ethoxyphenethylamine

Escaline is a mescaline analog studied for alkoxy-substituted phenethylamine pharmacology. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 8-12 hours
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Proscaline

3,5-Dimethoxy-4-propoxyphenethylamine

Proscaline is a mescaline derivative used in research on alkoxy phenethylamine structure-activity relationships.

Duration: 8-12 hours
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Allylescaline

3,5-Dimethoxy-4-allyloxyphenethylamine

Allylescaline is a substituted phenethylamine studied for mescaline analog pharmacology. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 8-12 hours
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2C-H

2,5-Dimethoxyphenethylamine

2C-H is a simple phenethylamine used in structure-activity relationship research as a baseline compound.

Duration: 4-8 hours
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2C-N

4-Nitro-2,5-dimethoxyphenethylamine

2C-N is a nitro-substituted phenethylamine studied for electron-withdrawing group effects on pharmacology.

Duration: 4-8 hours
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25P-NBOMe

25P-NBOMe is an N-benzyl phenethylamine used in high-potency 5-HT2A receptor research. This compound is widely used in analytical chemistry research as a reference standard and for pharmacological studies investigating receptor mechanisms and structure-activity relationships.

Duration: 6-10 hours
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Bromo-DragonFLY

DOB-DFLY

Bromo-DragonFLY is a benzodifuran phenethylamine studied for extremely long-acting psychedelic effects.

Duration: 18-36 hours
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Research Applications

Phenethylamines are studied in various research contexts including pharmacology, neuroscience, and consciousness studies. Researchers use these compounds to investigate:

  • Receptor binding profiles and affinity studies
  • Structure-activity relationships (SAR)
  • Metabolic pathways and pharmacokinetics
  • Comparative pharmacology with related compounds

Laboratory Safety Guidelines

Handling Precautions

  • Always use proper laboratory equipment and personal protective equipment (PPE)
  • Work in a well-ventilated area or fume hood
  • Use analytical scales for precise measurements
  • Store compounds according to manufacturer specifications

Testing

Always verify substance identity using reagent testing kits or analytical methods such as:

  • Gas chromatography-mass spectrometry (GC-MS)
  • Liquid chromatography-mass spectrometry (LC-MS)
  • Nuclear magnetic resonance (NMR) spectroscopy
  • Reagent color testing (Marquis, Ehrlich, etc.)

Legal Considerations

The legal status of Phenethylamines varies significantly by jurisdiction. Many countries have implemented analogue acts or blanket bans on entire chemical families.

Important: Always verify the legal status of specific compounds in your jurisdiction before ordering. EuroChems only ships to countries where compounds are legal for research purposes.

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