DMXE Powder

DMXE Powder, or 3-MeO-2′-Oxetamine, is a synthetic compound classified under the arylcyclohexylamine family. This substance is recognized for its structural similarity to other dissociative anesthetics, such as methoxetamine (MXE). DMXE is known for its unique physicochemical properties, which make it useful not only in research and development but also in certain practical applications. Below, we provide a detailed description of its characteristics, composition, handling, and potential uses.

Chemical Properties

DMXE Powder is characterized by its molecular formula C15H21NO2 and a molecular weight of approximately 247.33 g/mol. The compound contains an oxetane group, which contributes to its unique stability and binding profile. DMXE appears as a fine crystalline powder, typically white to off-white in color, although minor variations may occur depending on the manufacturing and purification processes.

The chemical structure of DMXE includes a cyclohexylamine backbone, with an ethoxy and methoxy substitution at specific positions. These structural features are responsible for its dissociative properties when interacting with NMDA receptors and other targets in biological systems. The compound maintains a high degree of purity when synthesized under controlled laboratory conditions, often exceeding 98%, ensuring both consistency and reliability for applications.

Solubility and Stability

DMXE Powder is moderately soluble in polar solvents such as ethanol, methanol, and acetone, making it compatible with various experimental procedures. It demonstrates lower solubility in non-polar solvents like hexane. The stability of DMXE is maximized when stored in a cool, dry environment away from direct light and moisture. Under optimal storage conditions, the shelf life of DMXE exceeds 12 months without significant degradation.

The compound can exhibit changes in solubility and behavior based on temperature, pH levels, and solvent type. It is essential to use appropriate storage containers, such as airtight and chemically inert materials, to avoid contamination or loss of effectiveness.

Applications

DMXE Powder is primarily intended for research purposes and should only be used by qualified professionals in a controlled laboratory setting. Its applications include (but are not limited to):

1. Pharmacological Studies:

DMXE’s interactions with NMDA receptors and its potential role in modulating neural pathways make it a subject of interest for neuroscience research. It is widely used in preclinical studies aimed at understanding dissociative anesthetic mechanisms.

2. Structure-Activity Relationship (SAR) Analysis:

Researchers often explore the relationship between DMXE’s molecular structure and its pharmacological activity. The compound serves as a benchmark to design analogs with enhanced efficacy and reduced side effects.

3. Toxicological Testing:

DMXE is employed in determining safety profiles, particularly in assessing cytotoxicity, bioavailability, and metabolic pathways in laboratory settings.

4. Chemical Synthesis:

DMXE can act as an intermediate in the synthesis of related arylcyclohexylamines, offering insight into developing alternative compounds for further investigation.

5. Analytical Standards:

Laboratories use high-purity DMXE Powder as a standard reference in analytical techniques such as high-performance liquid chromatography (HPLC), gas chromatography–mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR) spectroscopy.

Handling and Safety Guidelines

Proper handling of DMXE Powder is essential to maintain safety and minimize risks. The compound should only be manipulated wearing appropriate personal protective equipment (PPE), such as gloves, lab coats, and safety goggles. Always work in a well-ventilated fume hood to prevent inhalation of dust.

Safety Data:

• Physical State: Crystalline Powder
• Color: White to off-white
• Melting Point: ~120-125°C
• Boiling Point (estimated): Not applicable under standard atmospheric pressure
• Flash Point: Not determined

Hazards:

• May cause irritation if in contact with the skin, eyes, or respiratory system.
• Handle with care to avoid accidental ingestion, which can lead to toxicity.

First Aid Measures:

• Skin Contact: Wash thoroughly with soap and water.
• Eye Contact: Rinse immediately with clean water and seek medical attention if irritation persists.
• Inhalation: Move to fresh air and seek medical advice if respiratory symptoms occur.
• Accidental Exposure: Contact a certified medical professional immediately and provide the Safety Data Sheet (SDS) for reference.

Ensure proper disposal of DMXE waste according to local regulations. Do not allow the compound to enter waterways or public drainage systems.

Packaging and Storage

DMXE Powder is typically provided in sealed, tamper-proof containers to preserve its quality and prevent contamination. Packaging sizes vary based on requirements, ranging from small laboratory quantities to larger commercial orders. The containers are clearly labeled with all necessary hazard and storage instructions.

For long-term storage, maintain DMXE in a temperature range of 2–8°C in a climate-controlled environment. Avoid exposing the compound to extreme temperatures, fluxes in humidity, or direct UV light as these could compromise its integrity.

Regulatory Compliance

DMXE Powder is subject to legal restrictions and regulatory guidelines that vary between jurisdictions. It is the responsibility of the buyer to ensure compliance with local laws concerning its acquisition, possession, and use. The compound must only be purchased and handled by licensed professionals or institutions authorized to conduct research.

Summary

DMXE Powder is an advanced arylcyclohexylamine compound valued for its distinctive chemical properties and versatility in research applications. With high purity and solubility, combined with rigorous handling precautions, DMXE stands out as a reliable option for scientific investigations into the mechanisms of dissociative agents, NMDA receptor antagonism, and SAR studies. For optimal outcomes, users must adhere to best practices during handling and comply with all safety and regulatory requirements.